DLBCLMost common form of Non-Hodgkin’s lymphoma.

DLBCLMost common form of Non-Hodgkin’s lymphoma. It is a cancer of the B-lymphocytes. Accounts for 49% cases of Non-Hodgkin’s lymphoma (Gouveia, Siqueira, & Pereira, 2012).Case StudyPatient presented with DLBCL in the mediastinum and was at-risk of developing cardiovascular collapse.
Pathophysiology Multiple lesions in molecular pathways of B-lymphocyte differentiation and proliferation activates oncogenes. Increased expression of BCL2, BCL6 and MYC) Inactivation of tumor suppressor genes like p53 and INK4 (Akyurek et al, 2012)