Iron oxide nanoparticles coated with polyacrylic acid (PAA)

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Iron Oxide Nanoparticles Coated with Polyacrylic Acid (PAA)
The use of nanoparticles is showing signs of future success in the development and advancement of new biomedical applications. The property applies in areas such as cancer therapy, and drug delivery. It is also useful as a contrast agent in imagological techniques. They have chemical and physical properties such as biocompatibility and a high magnetic moment that make them useful for various new biomedical applications (Weinstein et al., 50). Several nanoparticles used for biomedical applications. However, the nanoparticles of Iron Oxide are the ones that are often used (Shubayev et al. 67). These enhance the biocompatibility, the nanoparticles of Iron oxide are coated with polyacrylic acid (PAA).
Iron Oxide nanoparticles are also used for magnetic recording as well. Particle size for iron Oxide coated with polyacrylic acid (PAA) is essential when it comes to its applications. Smaller particles with larger surface area exhibit different chemical and physical properties from the ones with larger particles. The coating of Iron Oxide with polyacrylic acid (PAA) helps to prevent aggregation. Aggregation leads to large particles. Smaller particles are preferred in most of the uses, especially biomedical field. Macrophages quickly realise large particles and removed from the blood.
However, as much as iron Oxide coated with polyacrylic acid (PAA) is essential in medical fields, its safety concern is still a debated matter.

The safety of PAA is yet to correct. Research has shown that the use of iron Oxide coated with polyacrylic acid (PAA) causes inflamed in the pathways, a raise in production of a more reactive species of oxygen and also cell death among other effects (Ahamed et al., 78). Further investigations and research should on these effects as well as the consequences of long-term exposure to Oxide coated with polyacrylic acid (PAA).
Work Cited
Chen, C. L., X. K. Wang, and M. Nagatsu. “Europium adsorption on multiwall carbon nanotube/iron oxide magnetic composite in the presence of polyacrylic acid.” Environmental science & technology 43.7 (2009): 2362-2367.
Fresnais, J., et al. “Poly (acrylic acid)-coated iron oxide nanoparticles: Quantitative evaluation of the coating properties and applications for the removal of a pollutant dye.” Journal of colloid and interface science 395 (2013): 24-30.
Mak, Sou‐Yee, and Dong‐Hwang Chen. “Binding and sulfonation of poly (acrylic acid) on Iron oxide nanoparticles: a novel, magnetic, strong acid cation nano‐adsorbent.” Macromolecular rapid communications 26.19 (2005): 1567-1571.