Outline & Proposal in a specific drug

Outline proposal of Amphetamine
An Evaluation of Euphoric Property of Amphetamines
Introduction:
Definition, Classification, and Features of Amphetamines (Heal et al., 2013).
How euphoria is related to addiction.
This paper will focus on amphetamine addiction and the implications of amphetamine addiction in enhancing performance.
This paper will emphasize the structure-function relationship of amphetamine in producing addiction and euphoria.
History and Background of Amphetamines
General information on the euphoric potential of amphetamines (Heal et al., 2013, Glennon, 2013).
Natural and Commercial Sources of Amphetamines.
Chemistry and Pharmacokinetic/Pharmacodynamic (PK/PD) properties of Amphetamines. (Should include ADME: Absorption, Distribution, Metabolism, and Excretion). Bioavailability and elimination half-life to be stated (Heal et al., 2013).
History (discovery of amphetamines, identification of the potential for addiction and substance abuse agent) (Heal et al., 2013).
Epidemiology of Amphetamine use
Need for Euphoria: Special focus on Amphetamines as a doping agent in competitive sports. Literature/evidence of performance enhancement potential of amphetamines.
Pathogenesis of Euphoria
The role of Amphetamines in stimulating Ventral tegmentum and Nucleus Accumbens to release dopamine (Spencer, Devilbiss & Berridge, 2015)
The impact of Amphetamine-Amphetamine receptor interaction on the reward-punishment pathway of our brain.
How amphetamine functions as dopamine agonist or potentiates the action of dopamine? ( Synergism and antagonism to be discussed)
The role of amphetamines on dopamine receptors?
Is there any cross-talk between amphetamines and other stimulants?(Lynch et al.

, 2013)
Potential for Addiction and Euphoria
Development of addiction and euphoria with Amphetamine use. Are such addictions transient or long lasting? (Lynch et al., 2013)
How addiction with Amphetamine does differ from addiction with other narcotics? (Discuss physiological effects, side effects, and toleration profile with amphetamine use}(Nestler, 2013)
Discuss the withdrawal effects, overdose and drug-drug interactions of amphetamines? (Ruffle, 2014)
Is there any measure to detect amphetamine and is there any correlation between the dose of amphetamine used and the extent of addiction/euphoria? (Lynch et al., 2013)
Comparison of euphoric potential or stimulant action of amphetamines, cocaine and LSD.
Management options
Discuss the different pharmacological and non-pharmacological interventions for managing amphetamine addiction (the past, present and pipeline drugs).
Explain the process and potential of rehabilitation ( strategies that are effective/ineffective, exploring the reasons for ineffective rehabilitation)
Future recommendation for specifying safe limits.
Discussion and Conclusion
Summarize main points of the paper and portray a conclusive image on the potential of Amphetamine as habit forming drugs: For example, comparison of amphetamines with cocaine or LSD or caffeine (Liddle & Connor, 2013).
Future research perspectives for combating and detecting amphetamine addiction.
Works Cited
Glennon RA (2013). “Phenylisopropylamine stimulants: amphetamine-related agents”. In
Lemke TL, Williams DA, Roche VF, Zito W. Foye’s principles of medicinal
chemistry (7th ed.). Philadelphia, USA: Wolters Kluwer Health/Lippincott Williams &
Wilkins. 646–648.
Heal DJ, Smith SL, Gosden J& Nutt DJ (June 2013). Amphetamines, Past & Present, A
pharmacological & clinical perspective. J. Psychopharmacol. 27 (6), 479–496
Lynch WJ, Peterson AB, Sanchez V, Abel J, & Smith MA (September 2013).Exercise a
novel treatment for drug addiction, Neurobiological Pathways.  Neurosci. Biobehav.
Rev. 37 (8), 1622–1644
Liddle., D. & Connor., D (June 2013). “Nutritional supplements and ergogenic AIDS”. Prim.
Care. 40 (2), 487–505
Nestler EJ (December 2013). “Cellular basis of memory for addiction”.Dialogues Clin.
Neurosci. 15 (4), 431–443.
 Ruffle JK (November 2014). “Molecular neurobiology of addiction: what’s all the (Δ)FosB
about?”. Am. J. Drug Alcohol Abuse. 40 (6), 428–437
Spencer RC, Devilbiss DM, Berridge CW (June 2015). “The Cognition-Enhancing Effects of
Psychostimulants Involve Direct Action in the Prefrontal Cortex”. Biol.
Psychiatry. 77 (11), 940–950.